SP-0351: Radiobiology in particle therapy

MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.

The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have ...

Introduction to Radiobiology of Targeted Radionuclide Therapy

During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a multidisciplinary approach that involves the cooperation of specialists in several research fields. Among them, radiobiologists investigate the biological effects of ionizing radiation, specifically the molecular and cellu...

Csis 0351 / Csis 8601 :

Consider the black box sampling problem that is described as follows. Suppose a black box contains red balls and blue balls. The number of red balls, which can be zero, is unknown. One is allowed to sample (with replacement) uniformly at random from the bag. Call an access to the black box positive if one samples a red ball and negative otherwise. The goal is to estimate the probability that an...

Radiobiology of Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy

References .......................................................................... 59 Abstract In recent years, increasing number of cancer patients are treated with stereotactic radiosurgery (SRS) or stereotactic body radiation therapy (SBRT), which deliver hypofractionated irradiation with high-dose per fraction . It is highly likely that the radiobiological principles such as 4 Rs (Reoxyg...

Thresholds in radiobiology.